If you like getting away from people fast... make the one hour drive from Sarasota to Everglades City/Chokoloskee. Its one of only three places you can enter into Everglades National Park. Great fishing for snook, trout, redfish, and tarpon. One of the best places to kayak fish in all of Florida. On your way back to Key West, fish Flamingo, near Homestead. This is the southernmost entrance into the Everglades, and the most incredible place I've ever fished. For kayakers, it doesn't get any better.
https://floridanationalparksassociation.com/everglades-national-park